DAO 119:67-74 (2016)  -  DOI: https://doi.org/10.3354/dao02979

Pharmacokinetics and residue depletion of praziquantel in rice field eels Monopterus albus 

Ning Xu1,2,3, Jing Dong1,2,3, Yibin Yang1, Xiaohui Ai1,3,*

1Freshwater Fish Germplasm Quality Supervision and Testing Center, Ministry of Agriculture, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, PR China
2Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, 214081, PR China
3Hu Bei Freshwater Aquaculture Collaborative Innovation Center, Wuhan 430070, PR China
*Corresponding author:

ABSTRACT: We investigated the pharmacokinetic characteristics of praziquantel (PZQ) in rice field eels Monopterus albus. Pharmacokinetic parameters were determined following a single intravenous administration (5 mg kg-1 body weight [bw]) and a single oral administration (10 mg kg-1 bw) at 22.0 ± 0.7°C. We also evaluated residue depletion in tissues following daily administration of PZQ (10 mg kg-1 bw) that was given orally for 3 consecutive days at 22.0 ± 0.7°C. Following intravenous treatment, the plasma concentration-time curve was best described by a 3-compartment open model, with distribution half-life (t1/2α), elimination half-life (t1/2β), and area under the concentration-time curve (AUC) of 0.54 h, 17.10 h, and 14505.12 h µg l-1, respectively. After oral administration, the plasma concentration-time curve was best described by a 1-compartment open model with first-order absorption, with absorption half-life (t1/2Ka), elimination half-life (t1/2Ke), peak concentration (Cmax), time-to-peak concentration (Tmax), and AUC estimated to be 2.28 h, 6.66 h, 361.29 µg l-1, 5.36 h, and 6065.46 h µg l-1, respectively. The oral bioavailability (F) was 20.9%. With respect to residue depletion of PZQ, the t1/2β values of muscle, skin, liver, and kidney were 20.2, 28.4, 14.9, and 54.1 h, respectively. Our results indicated rapid absorption, rapid elimination, and low bioavailability of PZQ in rice field eels at the tested dosing conditions.


KEY WORDS: Pharmacokinetics · Residue depletion · Praziquantel · Monopterus albus


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Cite this article as: Xu N, Dong J, Yang Y, Ai X (2016) Pharmacokinetics and residue depletion of praziquantel in rice field eels Monopterus albus . Dis Aquat Org 119:67-74. https://doi.org/10.3354/dao02979

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