DAO 121:29-35 (2016)  -  DOI: https://doi.org/10.3354/dao03032

Ceftiofur pharmacokinetics in Nile tilapia Oreochromis niloticus after intracardiac and intramuscular administrations

Waleed F. Khalil1,*, Hazem M. Shaheen2, Rania H. Abdou3

1Pharmacology Department, Faculty of Veterinary Medicine, University of Suez Canal, Ismailia 41522, Egypt
2Pharmacology Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt
3Departments of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, University of Suez Canal, Ismailia 41522, Egypt
*Corresponding author:

ABSTRACT: Ceftiofur is a broad-spectrum third generation cephalosporin, which acts by inhibiting bacterial cell wall synthesis. It is active against Gram-positive and Gram-negative bacteria such as Aeromonas hydrophila and β-lactamase-producing strains, which are common pathogens in freshwater fish. Ceftiofur pharmacokinetics in Nile tilapia  Oreochromis niloticus were studied following single intracardiac (i.c.) or intramuscular (i.m.) administration of ceftiofur sodium (NAXCEL®) in a dose of 5 mg ceftiofur kg-1 body weight. After i.c. injection, ceftiofur plasma concentrations decreased biexponentially, suggesting a 2-compartmental open model. Distribution and elimination half-lives (t0.5(α) and t0.5(β)) were 0.61 ± 0.22 and 0.14 ± 0.03 h mean ±SD, respectively. Elimination constant (Kel) and total body clearances (Cltot) were 3.22 ± 0.48 h-1 and 1.64 ± 0.47 l h-1 kg-1, respectively. Volume of distribution (Vss) and areas under curves (AUC) were 0.12 ± 0.03 l kg-1 and 24.18 ± 8.81 µg ml-1 h, respectively. Following i.m. injection of ceftiofur, plasma concentrations were best described by a 1-compartment open model with a first order absorption; bioavailability was quite high (96.85 ± 23.74%). Plasma maximum concentration (Cmax) was 12.32 ± 6.53 µg ml-1; achieved at time of maximum concentration (Tmax) of 0.74 ± 0.04 h. Absorption and elimination half-lives (t0.5(ab) and t0.5(β)) were 0.49 ± 0.06 and 0.53 ± 0.03 h, respectively. In conclusion, i.m. injection of ceftiofur sodium produced extremely high bioavailability with high plasma concentrations that persisted up to 6 h post injection, which may make ceftiofur a useful alternative antibiotic for treatment of brood stock or important ornamental fishes.


KEY WORDS: Ceftiofur · Cephalosporin · Pharmacokinetics · Teleosts · Tilapia · Intracardiac · Intramuscular


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Cite this article as: Khalil WF, Shaheen HM, Abdou RH (2016) Ceftiofur pharmacokinetics in Nile tilapia Oreochromis niloticus after intracardiac and intramuscular administrations. Dis Aquat Org 121:29-35. https://doi.org/10.3354/dao03032

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