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Diseases of Aquatic Organisms

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DAO 49:19-25 (2002)  -  doi:10.3354/dao049019

A syntenin-like protein with postsynaptic density protein (PDZ) domains produced by black tiger shrimp Penaeus monodon in response to white spot syndrome virus infection

Phuwadol Bangrak1, Potchanapond Graidist 2, Wilaiwan Chotigeat1, Kidchakan Supamattaya 3, Amornrat Phongdara1,*

1 Department of Biochemistry, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla 90110, Thailand
2 Department of Biotechnology, Faculty of Agro-Industry, Prince of Songkla University, Hat-Yai, Songkhla 90110, Thailand
3 Department of Aquatic Science, Faculty of Natural Resources, Prince of Songkla University, Hat-Yai, Songkhla 90110, Thailand
*Corresponding author. E-mail:

ABSTRACT: We report the isolation and characterization of products from a subtractive cDNA library from the haemolymph of Penaeus monodon experimentally infected with white spot syndrome virus (WSSV). One cDNA derived from up-regulated mRNA was identified. A homology search indicated similarity to the putative protein syntenin (TE8). The nearly complete nucleotide sequence of TE8 was obtained by rapid amplification of cDNA (RACE). Its putative protein product contained a tandem repeat of PDZ domains (postsynaptic density protein or PSD-95, DlgA and ZO-1). We propose that TE8 may function as an adapter that couples PDZ-binding protein(s) in a signaling pathway involved in the shrimp response to WSSV.


KEY WORDS: White spot syndrome virus · Penaeus monodon · Signal transduction · Syntenin · Postsynaptic density protein · PDZ


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