DAO 82:231-236 (2008)  -  DOI: https://doi.org/10.3354/dao01987

Pharmacokinetics of danofloxacin after single dose intravenous, intramuscular and subcutaneous administration to loggerhead turtles Caretta caretta

Pedro Marín1,*, Alejandro Bayón2, Emilio Fernández-Varón1, Elisa Escudero1, Cristina Clavel2, Ramon Almela3, Carlos M. Cárceles1

1Department of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, Campus de Espinardo, 30.071-Murcia, Spain
2Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, Campus de Espinardo, 30.071-Murcia, Spain
3Veterinary Teaching Hospital, University of Murcia, Campus de Espinardo, 30.071-Murcia, Spain

ABSTRACT: The single-dose disposition kinetics of the antibiotic danofloxacin were determined in clinically normal loggerhead turtles (n = 6) after intravenous (IV), subcutaneous (SC) and intramuscular (IM) administration of 6 mg kg–1 bodyweight. Danofloxacin concentrations were determined by high performance liquid chromatography with fluorescence detection. The concentration–time data were analyzed by non-compartmental kinetic methods. Steady-state volume of distribution, and total body clearance of danofloxacin after IV administration were estimated to be 1.02 ± 0.17 l kg–1 and 0.11 ± 0.01 l h–1 kg–1, respectively. Following IM and SC administration, danofloxacin achieved maximum plasma concentrations of 10.25 ± 4.59 and 10.35 ± 4.45 mg l–1 at 1.20 ± 0.52 and 1.46 ± 0.48 h, respectively. The absolute bioavailabilities after SC and IM routes were 98.72 ± 11.73 and 104.81 ± 14.97%, respectively. Danofloxacin shows a favourable pharmacokinetic profile in loggerhead turtles reflected by parameters such as a long half-life and a high bioavailability following a single dose of 6 mg kg–1 by IM and SC routes; thus, it is likely that this treatment will be effective in loggerhead turtles with bacterial infections.


KEY WORDS: Danofloxacin · Pharmacokinetics · Loggerhead turtle · Bioavailability · Caretta caretta


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Cite this article as: Marín P, Bayón A, Fernández-Varón E, Escudero E, Clavel C, Almela R, Cárceles CM (2008) Pharmacokinetics of danofloxacin after single dose intravenous, intramuscular and subcutaneous administration to loggerhead turtles Caretta caretta. Dis Aquat Org 82:231-236. https://doi.org/10.3354/dao01987

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