DAO 83:257-260 (2009)  -  doi:10.3354/dao02008

NOTE
Using itraconazole to clear Batrachochytrium dendrobatidis infection, and subsequent depigmentation of Alytes muletensis tadpoles

T. W. J. Garner1,*, G. Garcia2, B. Carroll3, M. C. Fisher3

1Institute of Zoology, Zoological Society of London, Regent’s Park, London NW1 4RY, UK
2Durrell Wildlife Conservation Trust, Les Augrès Manor, Trinity, Jersey JE3 5BP, UK
3Department of Infectious Disease Epidemiology, Imperial College, St. Mary’s Campus, Norfolk Place, London W2 1PG, UK

ABSTRACT: Batrachochytrium dendrobatidis (Bd) is a global threat to amphibian biodiversity. Current calls for conservation through captive breeding require that efficient and reliable antifungal treatments be developed for target species. Here we confirm that the antifungal itraconazole is an effective treatment for infection in larval Alytes muletensis. Exceptionally low doses applied as few as 7 times were effective at clearing infection from tadpoles for up to 28 d after treatment. However, we cannot recommend itraconazole as a treatment for this species as depigmentation of tadpoles was observed. Further research is required to determine the putative hepatotoxicity of this treatment.


KEY WORDS: Batrachochytrium dendrobatidis · Antifungal treatment · Tadpole · Depigmentation


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Cite this article as: Garner TWJ, Garcia G, Carroll B, Fisher MC (2009) Using itraconazole to clear Batrachochytrium dendrobatidis infection, and subsequent depigmentation of Alytes muletensis tadpoles. Dis Aquat Org 83:257-260

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