DAO 107:113-120 (2013)  -  DOI: https://doi.org/10.3354/dao02666

Detection of novel strains of cyprinid herpesvirus closely related to koi herpesvirus

Marc Y. Engelsma1, Keith Way2, Melanie J. Dodge2, Michal Voorbergen-Laarman1, Valentina Panzarin3, Miriam Abbadi3, Mansour El-Matbouli4, Helle Frank Skall5, Søren Kahns5,6, David M. Stone2,*

1Central Veterinary Institute (CVI), part of Wageningen UR, PO Box 65, 8200 AB Lelystad, The Netherlands
2Cefas, Barrack Road, The Nothe, Weymouth, Dorset DT4 8UB, UK
3Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell’Universita 10, 35020 Legnaro, Padova, Italy
4University of Veterinary Medicine, Vienna, Veterinärplatz 1, 1210 Vienna, Austria
5National Veterinary Institute (DTU-Vet), Technical University of Denmark, Hangøvej 2, 8200 Aarhus N, Denmark
6Present address: Danish Technological Institute, Kongsvang Allé 29, 8000 Aarhus C, Denmark
*Corresponding author. Email:

ABSTRACT: Cyprinid herpesvirus 3 (CyHV-3) or koi herpesvirus (KHV) is a devastating virus of carp. Using generic primers for the DNA polymerase and the major capsid protein genes of cyprinid herpesviruses, nucleotide sequences divergent from previously described CyHV-3 were obtained. At least 3 novel groups of putative CyHV-3-like viruses were identified, sharing 95 to 98% nucleotide identity with CyHV-3 strains. Carp carrying the CyHV-3 variants did not show clinical signs consistent with CyHV-3 infection and originated from locations with no actual CyHV-3 outbreaks. These strains might represent low- or non-pathogenic variants of CyHV-3.

KEY WORDS: Carp · Alloherpesviridae · Phylogeny · CyHV-3 · Variant strains

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Cite this article as: Engelsma MY, Way K, Dodge MJ, Voorberger-Laarman M and others (2013) Detection of novel strains of cyprinid herpesvirus closely related to koi herpesvirus. Dis Aquat Org 107:113-120. https://doi.org/10.3354/dao02666

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