Diseases of Aquatic Organisms
DAO is a hybrid research journal on all aspects of disease phenomena in aquatic organisms.
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DOI: https://doi.org/10.3354/dao02773
copiedInteraction between type I interferon and cyprinid herpesvirus 3 in two genetic lines of common carp Cyprinus carpio
- Mikołaj Adamek
- Krzysztof Ł. Rakus
- Graham Brogden
- Marek Matras
- Jarosław Chyb
- Ikuo Hirono
- Hidehiro Kondo
- Takashi Aoki
- Ilgiz Irnazarow
- Dieter Steinhagen
ABSTRACT: Cyprinid herpesvirus 3 (CyHV-3) infection in common carp Cyprinus carpio L. and its ornamental koi varieties can induce the severe systemic disease known as koi herpesvirus disease. This disease is characterised by a rapid replication and spreading of the virus through multiple organs and results in a fast onset of mortality (starting on Day 6 post infection) in up to 100% of infected fish. During the first phase of viral infections, type I interferons (IFNs) have generally been proven to be essential in inducing an innate immune response; however, very little is known about the type I IFN response to herpesviruses in fish. The aim of this work was to study the type I IFN responses during CyHV-3 infection in 2 genetically divergent lines of common carp which presented differing survival rates. Our results show that CyHV-3 induced a systemic type I IFN response in carp, and the magnitude of type I IFN expression is correlated with the virus load found in skin and head kidney. In this in vivo experimental setup, the level of type I IFN response cannot be linked with higher survival of carp during CyHV-3 infection.
KEYWORDS
Mikołaj Adamek (Co-author)
- Fish Disease Research Unit, Centre of Infectious Diseases, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany
- Polish Academy of Sciences, Institute of Ichthyobiology & Aquaculture in Gołysz, Kalinowa 2, 43-520 Chybie, Poland
- Department of Ichthyobiology and Fisheries, University of Agriculture, 30-199 Kraków-Mydlniki, Poland
Krzysztof Ł. Rakus (Co-author)
- Polish Academy of Sciences, Institute of Ichthyobiology & Aquaculture in Gołysz, Kalinowa 2, 43-520 Chybie, Poland
Graham Brogden (Co-author)
- Fish Disease Research Unit, Centre of Infectious Diseases, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany
Marek Matras (Co-author)
- Laboratory of Fish Diseases, National Veterinary Research Institute, Partyzantów 57, 24-100 Puławy, Poland
Jarosław Chyb (Co-author)
- Department of Ichthyobiology and Fisheries, University of Agriculture, 30-199 Kraków-Mydlniki, Poland
Ikuo Hirono (Co-author)
- Laboratory of Genome Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato, Tokyo 108-8477, Japan
Hidehiro Kondo (Co-author)
- Laboratory of Genome Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato, Tokyo 108-8477, Japan
Takashi Aoki (Co-author)
- Laboratory of Genome Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato, Tokyo 108-8477, Japan
Ilgiz Irnazarow (Co-author)
- Polish Academy of Sciences, Institute of Ichthyobiology & Aquaculture in Gołysz, Kalinowa 2, 43-520 Chybie, Poland
Dieter Steinhagen (Co-author)
- Fish Disease Research Unit, Centre of Infectious Diseases, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany