DAO 111:107-118 (2014)  -  DOI: https://doi.org/10.3354/dao02773

ABSTRACT: Cyprinid herpesvirus 3 (CyHV-3) infection in common carp Cyprinus carpio L. and its ornamental koi varieties can induce the severe systemic disease known as koi herpesvirus disease. This disease is characterised by a rapid replication and spreading of the virus through multiple organs and results in a fast onset of mortality (starting on Day 6 post infection) in up to 100% of infected fish. During the first phase of viral infections, type I interferons (IFNs) have generally been proven to be essential in inducing an innate immune response; however, very little is known about the type I IFN response to herpesviruses in fish. The aim of this work was to study the type I IFN responses during CyHV-3 infection in 2 genetically divergent lines of common carp which presented differing survival rates. Our results show that CyHV-3 induced a systemic type I IFN response in carp, and the magnitude of type I IFN expression is correlated with the virus load found in skin and head kidney. In this in vivo experimental setup, the level of type I IFN response cannot be linked with higher survival of carp during CyHV-3 infection.

KEY WORDS: CyHV-3 · Koi · Infection · Innate immune response · Interferon stimulated genes

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Cite this article as: Adamek M, Rakus KŁ, Brogden G, Matras M and others (2014) Interaction between type I interferon and cyprinid herpesvirus 3 in two genetic lines of common carp Cyprinus carpio. Dis Aquat Org 111:107-118. https://doi.org/10.3354/dao02773 Export citation Share:    Facebook - - linkedIn