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Diseases of Aquatic Organisms

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DAO 113:127-135 (2015)  -  DOI:

Expression of immune-related genes of common carp during cyprinid herpesvirus 3 infection

Agus Sunarto1,2, Kenneth A. McColl1,*

1CSIRO Biosecurity Flagship, Australian Animal Health Laboratory, Geelong, VIC 3220, Australia
2AMFRD Centre for Aquaculture Research and Development, Fish Health Research Laboratory, Jakarta 12540, Indonesia
*Corresponding author:

ABSTRACT: Fish herpesviruses and their hosts may have coevolved for 400 to 450 million yr. During this coexistence, the hosts have equipped themselves with an elaborate immune system to defend themselves from invading viruses, whereas the viruses have developed strategies to evade host immunity, including the expression of cytokine genes that have been captured from the host. Taking advantage of our experimental model for cyprinid herpesvirus 3 (CyHV-3) persistence in carp, we studied the gene expression of host and virus immune-related genes in each stage of infection: acute, persistent and reactivation phases. IFNγ-1, IFNγ-2, IL-12 and IL-10 host genes, and the CyHV-3 vIL-10 gene (khvIL-10) were highly significantly up-regulated in different phases of CyHV-3 infection. Similarly, host IL-1β was up-regulated in the acute phase of CyHV-3 infection. There was no significant difference in the expression of host TNFα-1 and MHC-II genes during all phases of CyHV-3 infection. Based on the expression profile of carp immune-related genes in each stage of CyHV-3 infection, we propose a possible interaction between carp IL-12, carp IL-10 and khvIL-10 during the course of viral infection. To our knowledge, this is the first report on the expression of cytokine genes during all phases (acute, persistent and reactivation) of CyHV-3 infection.

KEY WORDS: Cyprinid herpesvirus 3 · Koi herpesvirus · Immune response · Gene expression profiling · Persistent infection · Latent infection · Cyprinus carpio

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Cite this article as: Sunarto A, McColl KA (2015) Expression of immune-related genes of common carp during cyprinid herpesvirus 3 infection. Dis Aquat Org 113:127-135.

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