DAO 131:73-78 (2018)  -  DOI: https://doi.org/10.3354/dao03282

NOTE
Itraconazole and thiophanate-methyl fail to clear tadpoles naturally infected with the hypervirulent lineage of Batrachochytrium dendrobatidis

Andrés Fernández-Loras1, Bárbara Martín-Beyer1, Trenton W. J. Garner2,3, Jaime Bosch1,4,*

1Museo Nacional de Ciencias Naturales-CSIC, 28006 Madrid, Spain
2Institute of Zoology, Zoological Society of London, Regent’s Park, London NW1 4RY, UK
3Unit for Environmental Research and Management, North-West University, Potchefstroom 2520, South Africa
4Centro de Investigación, Seguimiento y Evaluación, Parque Nacional de la Sierra de Guadarrama, 28740 Rascafría, Spain
*Corresponding author:

ABSTRACT: The emerging infectious disease chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis, is a major driver pushing many amphibian species to the brink of extinction. Substantial efforts to develop effective protocols that use antifungal drugs have had notable success. Here, we used the antifungal agents itraconazole and thiophanate-methyl, singly and in combination, in an attempt to treat common midwife toad Alytes obstetricans larvae naturally infected with the globalized hypervirulent lineage of B. dendrobatidis. Despite the successful use of itraconazole in a closely related species (A. muletensis), our results show that these antifungal treatments are not always effective and that full clearance of animals cannot be assumed following treatment.


KEY WORDS: Chytridiomycosis · Itraconazole · Thiophanate-methyl · Alytes obstetricans


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Cite this article as: Fernández-Loras A, Martín-Beyer B, Garner TWJ, Bosch J (2018) Itraconazole and thiophanate-methyl fail to clear tadpoles naturally infected with the hypervirulent lineage of Batrachochytrium dendrobatidis. Dis Aquat Org 131:73-78. https://doi.org/10.3354/dao03282

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