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Diseases of Aquatic Organisms

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DAO 137:73-79 (2019)  -  DOI:

White spot syndrome virus down-regulates expression of histones H2A and H4 of Penaeus vannamei to promote viral replication

Trinidad Encinas-García1, Daynette Lorely Loreto-Quiroz2, Fernando Mendoza-Cano1, Alberto Peña-Rodriguez3, Diana Fimbres-Olivarria4, Enrique de la Re-Vega4, Arturo Sánchez-Paz1,*

1Laboratorio de Análisis, Referencia y Diagnóstico en Sanidad Acuícola, Centro de Investigaciones Biológicas del Noroeste (CIBNOR), Calle Hermosa 101, Col. Los Ángeles, Hermosillo, Sonora 83106, México
2División de Ciencias Biológicas, Universidad de la Sierra, Carretera Moctezuma-Cumpas Km. 2.5, Moctezuma, Sonora 84560, México
3Centro de Investigaciones Biológicas del Noroeste (CIBNOR), Av. Instituto Politécnico Nacional No. 195, Col. Playa Palo de Santa Rita, La Paz, Baja California Sur 23096, México
4Departamento de Investigaciones Científicas y Tecnológicas (DICTUS), Universidad de Sonora, Hermosillo, Sonora 83000, México
*Corresponding author:

ABSTRACT: The white spot syndrome virus (WSSV) is a highly lethal and contagious pathogen to most cultivated shrimp species. The WSSV genome contains the ICP11 gene and its encoded protein acts as a multifunctinal DNA mimic protein that disrupts the nucleosome assembly by binding to the histone proteins H2A and H3. In addition, WSSV provokes severe nuclear hypertrophy and DNA damage. However, little is known about the influence of WSSV on the expression of the host’s genes encoding for histones. Therefore, we investigated the effect of WSSV infection on the expression of the genes encoding histones in shrimp Penaeus vannamei. An RT-qPCR assay was performed to evaluate the temporal expression of H2A and H4 transcripts in the shrimp. Significant changes were observed in the expression of these genes, which coincided with the dynamics of replication of the virus. H2A reached its maximum expression levels at 12 hpi. Thus, it may be suggested that this is a viral strategy to evade the host’s immune response in order to promote viral replication.

KEY WORDS: WSSV · Histones · H2A · H4 · Immune evasion · Viral replication

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Cite this article as: Encinas-García T, Loreto-Quiroz DL, Mendoza-Cano F, Peña-Rodriguez A, Fimbres-Olivarria D, de la Re-Vega E, Sánchez-Paz A (2019) White spot syndrome virus down-regulates expression of histones H2A and H4 of Penaeus vannamei to promote viral replication. Dis Aquat Org 137:73-79.

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