Inter-Research > DAO > v137 > n3 > p205-210  
Diseases of Aquatic Organisms

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DAO 137:205-210 (2020)  -  DOI:

Spontaneous adenocarcinoma of the gas gland in Nothobranchius fishes

Iva Dyková1,*, Radim Blažek2, Kamila Součková3, Martin Reichard2, Ondřej Slabý3,4

1Institute of Botany and Zoology, Masaryk University, Brno 60137, Czech Republic
2Institute of Vertebrate Biology, Czech Academy of Sciences, Brno 60365, Czech Republic
3Central European Institute of Technology, Masaryk University, Brno 62400, Czech Republic
4Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno 60200, Czech Republic
*Corresponding author:

ABSTRACT: Nothobranchius fishes (Cyprinodontiformes), known for their genetically encoded extremely compressed lifespan, are considered an excellent vertebrate model for the research of aging. Unlike the rapid accumulation of data concerning their biology, ecology and genome, knowledge of their age-related diseases, including tumours, is still very limited. This Note reports spontaneous neoplastic lesions in the swim bladder gas glands of Nothobranchius furzeri, N. kadleci and N. orthonotus. Based on light and transmission electron microscopy, the neoplastic proliferation of gas gland cells was classified as adenocarcinoma. There was a concurrent proliferation of haemopoietic cells in the kidney interstitium in all individuals diagnosed with this type of primary neoplasia.

KEY WORDS: Nothobranchius fishes · Spontaneous neoplasia · Gas gland adenocarcinoma

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Cite this article as: Dyková I, Blažek R, Součková K, Reichard M, Slabý O (2020) Spontaneous adenocarcinoma of the gas gland in Nothobranchius fishes. Dis Aquat Org 137:205-210.

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