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Diseases of Aquatic Organisms

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DAO 145:165-172 (2021)  -  DOI: https://doi.org/10.3354/dao03606

Histological assessment of systemic granulomatosis progression in meagre Argyrosomus regius during cage ongrowing phase

Andrea Gustinelli1,*, Slavica Čolak2, Francesco Quaglio3, Rubina Sirri1, Matko Kolega2, Danijel Mejdandžić2, Monica Caffara1, Renata Baric2, Maria Letizia Fioravanti1

1Department of Veterinary Medical Sciences, Alma Mater Studiorum University of Bologna, 40064 Ozzano Emilia (BO), Italy
2CROMARIS d.d., 23000 Zadar, Croatia
3Department of Comparative Biomedicine and Food Science, University of Padova, 35020 Legnaro (PD), Italy
*Corresponding author:

ABSTRACT: Meagre Argyrosomus regius is a potential candidate for Mediterranean aquaculture diversification, although several health issues still represent important bottlenecks for its sustainable production, including systemic granulomatosis (SG). To evaluate the SG progression in meagre during a 10 mo period of cage ongrowing, a histopathological investigation was carried out on 108 meagre fed 3 different diets (commercial pellets, hydrated commercial pellets and defrosted sardines). Histological sections of the gills and visceral organs were examined and lesions referable to SG scored from 1-3 according to the severity of the granulomatosis. The kidney and liver were the most affected organs, showing the highest percentage of positivity for granulomas and severity of lesions along the whole observation period. Using a statistical mixed model (GLMM) followed by odds ratio analysis, an effect of diet and temperature was found: the severity of liver and digestive tract SG scores decreased in the Cage 3 group (defrosted sardines) and with increasing temperature (p < 0.05, negative estimates, odds ratio <1). These observations, in accordance with the literature, suggest that SG in meagre could be related to nutritional-metabolic factors with the possible influence of environmental factors such as temperature.


KEY WORDS: Systemic granulomatosis · Meagre · Argyrosomus regius · Aquaculture


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Cite this article as: Gustinelli A, Čolak S, Quaglio F, Sirri R and others (2021) Histological assessment of systemic granulomatosis progression in meagre Argyrosomus regius during cage ongrowing phase. Dis Aquat Org 145:165-172. https://doi.org/10.3354/dao03606

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