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Diseases of Aquatic Organisms

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DAO 156:1-6 (2023)  -  DOI:

B-cell small lymphocytic lymphoma in a free-ranging South American fur seal (Arctocephalus australis)

Derek B. de Amorim1,2,3,*, Paula R. Ribeiro1,2, Marcele B. Bandinelli2, Joanna V. Z. Echenique1,2, Matheus V. Bianchi2, Paula R. Almeida4, Fernando R. Spilki4, Leticia F. Baumbach5,6, Luciana Sonne1,2

1Programa de Pós-graduação em Ciências Veterinárias (PPGCV) Faculdade de Veterinária, (FAVET), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 91540-000, Brazil
2Setor de Patologia Veterinária (SPV), FAVET, UFRGS, Porto Alegre, RS 91540-000, Brazil
3Centro de Estudos Costeiros, Limnológicos e Marinhos (CECLIMAR), Campus Litoral Norte (CLN), UFRGS, Imbé, RS 95625-000, Brazil
4Laboratório de Microbiologia Molecular, Instituto de Ciências da Saúde, Universidade Feevale, Novo Hamburgo, RS 93352-000, Brazil
5Programa de Pós-Graduação em Biologia Celular e Molecular (PPGBCM), Centro de Biotecnologia (CBiot), UFRGS, CP 15005, Porto Alegre, RS 91501-970, Brazil
6Laboratório de Virologia Veterinária (LabViroVet), FAVET, UFRGS, Porto Alegre, RS 91540-000, Brazil
*Corresponding author:

ABSTRACT: Lymphomas are malignant neoplasms of the hematopoietic system arising from lymphocytes with highly variable biologic behavior. B-cell small lymphocytic lymphoma (B-SLL) is a non-Hodgkin lymphoma infrequently described in domestic and wild animals. The present study describes a case of B-SLL in a free-ranging adult male Arctocephalus australis in Brazil. The main necropsy findings included poor body condition, generalized lymphadenomegaly, severe and diffuse splenomegaly, and multiple, white to yellow nodules in the kidneys and small intestine. Histologically, these organs were partially or totally effaced by neoplastic small lymphocytes arranged in sheets, with moderate anisocytosis and anisokaryosis and a low mitotic count. These cells diffusely immunolabeled for CD79α and CD20, and were negative for CD3. A diagnosis of multicentric B-SLL was established and to the authors’ knowledge, it has not been previously described in this genus.

KEY WORDS: Lymphoma · B-cell · Pinniped · Arctocephalus · Fur seal

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Cite this article as: de Amorim DB, Ribeiro PR, Bandinelli MB, Echenique JVZ and others (2023) B-cell small lymphocytic lymphoma in a free-ranging South American fur seal (Arctocephalus australis). Dis Aquat Org 156:1-6.

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