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Diseases of Aquatic Organisms

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DAO 43:71-76 (2000)  -  doi:10.3354/dao043071

Nucleotide sequence variation in isolates of infectious salmon anaemia virus (ISAV) from Atlantic salmon Salmo salar in Scotland and Norway

J. A. Inglis, J. Bruce, C. O. Cunningham*

FRS Marine Laboratory, PO Box 101, Victoria Road, Aberdeen AB11 9DB, United Kingdom
*Corresponding author. E-mail:

ABSTRACT: The nucleotide sequences of segments 2 and 8 of infectious salmon anaemia virus (ISAV) isolates from Scotland and Norway were determined and compared. Sequence variations were found in both segments, with segment 2 being more variable. These variations were of the same degree as those found in previous comparisons of the first recorded strain of ISAV in Scotland and Norwegian strains for which sequence information was available. The sequences again demonstrate the separation of European and Canadian strains of ISAV but, as is expected for an RNA virus, reveal that the European ISAV is not homogeneous. These results demonstrate the value of nucleotide sequences as a tool for strain identification and epidemiological investigation of ISAV.

KEY WORDS: Infectious salmon anaemia virus · ISAV · Atlantic salmon · Salmo salar · Nucleotide sequence

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