DAO 44:133-136 (2001)  -  doi:10.3354/dao044133

ABSTRACT: The effect of cimetidine on the treatment efficacy of praziquantel against Microcotyle sebastis infestation in cultured rockfish Sebastes schlegeli was investigated. Juvenile rockfish were divided into 7 groups, and orally administered praziquantel alone (50, 100 and 200 mg kg^-1 body wt, BW) or in combination with cimetidine at a dose of 200 mg kg^-1 BW for each praziquantel dose. The fish in the control group were administered only saline. The results clearly showed that coadministration of cimetidine with praziquantel led to a significantly increased treatment efficacy of the latter drug, and consequently would lead to a lowering of the total dose of praziquantel, and a reduction in the administration times and costs for the treatment of M. sebastis infestation in cultured rockfish.

KEY WORDS: Praziquantel · Cimetidine · Microcotyle sebastis · Sebastes schlegeli · Treatment efficacy