Inter-Research > DAO > v44 > n2 > p133-136  
Diseases of Aquatic Organisms

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DAO 44:133-136 (2001)  -  doi:10.3354/dao044133

Treatment of Microcotyle sebastis infestation in cultured rockfish Sebastes schlegeli by oral administration of praziquantel in combination with cimetidine

Ki Hong Kim*, Eun Hae Lee, Se Ryun Kwon, Jae Bum Cho

Department of Aquatic Life Medicine, College of Fisheries Science, Pukyong National University, Pusan 608-737, Korea

ABSTRACT: The effect of cimetidine on the treatment efficacy of praziquantel against Microcotyle sebastis infestation in cultured rockfish Sebastes schlegeli was investigated. Juvenile rockfish were divided into 7 groups, and orally administered praziquantel alone (50, 100 and 200 mg kg-1 body wt, BW) or in combination with cimetidine at a dose of 200 mg kg-1 BW for each praziquantel dose. The fish in the control group were administered only saline. The results clearly showed that coadministration of cimetidine with praziquantel led to a significantly increased treatment efficacy of the latter drug, and consequently would lead to a lowering of the total dose of praziquantel, and a reduction in the administration times and costs for the treatment of M. sebastis infestation in cultured rockfish.

KEY WORDS: Praziquantel · Cimetidine · Microcotyle sebastis · Sebastes schlegeli · Treatment efficacy

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