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Diseases of Aquatic Organisms

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DAO 46:159-163 (2001)  -  doi:10.3354/dao046159

Transmission of the Ambystoma tigrinum virus to alternative hosts

James K. Jancovich1, Elizabeth W. Davidson1,*, April Seiler1, Bertram L. Jacobs2, James P. Collins1

1Department of Biology, and
2Department of Microbiology, Molecular and Cellular Biology Program, Arizona State University, Tempe, Arizona 85287, USA
*Corresponding author. E-mail:

Abstract: Ambystoma tigrinum virus (ATV) is a lethal virus originally isolated from Sonora tiger salamanders Ambystoma tigrinum stebbinsi in the San Rafael Valley in southern Arizona. USA. ATV is implicated in several salamander epizootics. We attempted to transmit ATV experimentally to fish and amphibians by injection, water bath exposure, or feeding to test whether ATV can cause clinical signs of infection or be recovered from exposed individuals that do not show clinical signs. Cell culture and polymerase chain reaction of the viral major capsid protein gene were used for viral detection. Salamanders and newts became infected with ATV and the virus was recovered from these animals, but virus could not be recovered from any of the frogs or fish tested. These results suggest that ATV may only infect urodeles and that fish and frogs may not be susceptible to ATV infection.

KEY WORDS: Ranavirus · Salamander · Frog · Fish · Polymerase chain reaction · Cell culture · Amphibian decline

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Cite this article as: Jancovich JK, Davidson EW, Seiler A, Jacobs BL, Collins JP (2001) Transmission of the Ambystoma tigrinum virus to alternative hosts. Dis Aquat Org 46:159-163.

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