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Diseases of Aquatic Organisms

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DAO 49:39-44 (2002)  -  doi:10.3354/dao049039

Flumequine in Atlantic salmon Salmo salar: disposition in fish held in sea water versus fresh water

Sidsel Sohlberg1,*, Kristian Ingebrigtsen1, Magne K. Hansen1, William L. Hayton2, Tor Einar Horsberg1

1 Department of Pharmacology, Microbiology, and Food Hygiene, The Norwegian School of Veterinary Science, PO Box 8146 Dep., 0033 Oslo, Norway
2 Ohio State University, College of Pharmacy, Columbus, Ohio 43210, USA

ABSTRACT: 14C-labeled flumequine was administered as a single oral (5 mg kg-1, 86 µCi kg-1) or intravenous (5 mg kg-1, 82 µCi kg-1) dose to Atlantic salmon Salmo salar held in sea water or in fresh water. The absorption, tissue distribution and elimination were determined by means of liquid scintillation counting and whole-body autoradiography. The drug was rapidly absorbed and extensively distributed in all groups of fish. Radiolabeled compound was present in blood and muscle for more than 8 wk in the freshwater groups. In the seawater groups, however, no radioactivity was detected in the blood and muscle after 4 d and 2 wk, respectively. It was concluded that flumequine was eliminated at a substantially higher rate from Atlantic salmon in sea water than in fresh water.

KEY WORDS: Flumequine · Kinetics · Whole-body autoradiography · Atlantic salmon

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