Inter-Research > DAO > v56 > n3 > p195-200  
Diseases of Aquatic Organisms

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DAO 56:195-200 (2003)  -  doi:10.3354/dao056195

Effect of intraperitoneally administered IL-1β-derived peptides on resistance to viral haemorrhagic septicaemia in rainbow trout Oncorhynchus mykiss

Scott Peddie1,3, Pamela E. McLauchlan1,2, Anthony E. Ellis2, Christopher J. Secombes1,*

1School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
2SEERAD Marine Laboratory, PO Box 101, Victoria Road, Aberdeen AB11 9DB, UK
3Present address: Animal Health Economics Group, Research & Development Division, Scottish Agricultural College, Aberdeen AB21 9YA, UK
*Corresponding author. Email:

ABSTRACT: The present work provides the first information concerning the immunostimulatory activity of trout interleukin (IL)-1β-derived peptides in vivo. Previous studies have demonstrated the ability of 2 such peptides, referred to as P1 and P3, to up-regulate a range of important immune parameters in vitro. P1 corresponds to fragment 146-157 (YVTPVPIETEAR) of the trout sequence and is analogous to a biologically active mammalian IL-1

KEY WORDS: Interleukin-1β · Phagocytosis · Respiratory burst · Disease resistance · Immunomodulation · VHS

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