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Diseases of Aquatic Organisms

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DAO 86:263-272 (2009)  -  DOI:

RNA interference-based therapeutics for shrimp viral diseases

P. Krishnan, P. Gireesh-Babu*, K. V. Rajendran, Aparna Chaudhari

Central Institute of Fisheries Education, Indian Council of Agricultural Research, Seven Bungalows, Andheri West, Versova, Mumbai-400061, India
*Corresponding author. Email:

ABSTRACT: RNA interference (RNAi) has emerged as a powerful tool to manipulate gene expression in the laboratory. The presence of a double-stranded RNA (dsRNA) in eukaryotic cells triggers this post-transcriptional gene-silencing mechanism, leading to a sequence-specific degradation of the target mRNA. Among its many potential biomedical applications, silencing of viral genes stands out as a promising therapeutic strategy. Marine shrimp viral diseases, especially white spot disease (WSD), represents one of the most attractive targets for the development of therapeutic RNAi owing to its widespread economic impact. This review summarizes the current knowledge in the therapeutic application of RNAi for combating viral diseases in shrimp. The basic principles of RNAi are described, focusing on features important for its therapeutic manipulation. Subsequently, a stepwise strategy for the development of therapeutic RNAi is presented.

KEY WORDS: RNAi therapy · Shrimp diseases · Small interfering RNA · siRNA · Long hairpin RNA · lhRNA

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Cite this article as: Krishnan P, Gireesh Babu P, Rajendran KV, Chaudhari A (2009) RNA interference-based therapeutics for shrimp viral diseases. Dis Aquat Org 86:263-272.

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