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Diseases of Aquatic Organisms

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DAO 94:117-124 (2011)  -  DOI:

Short-term infection of striped bass Morone saxatilis with Mycobacterium marinum

Soo Jin Jeon1, Lonnie C. Gonsalves2,3, John M. Jacobs3, Matt Rhodes3, Jimmy Councilman3, Ana Baya3, Eric B. May2, Mark D. Fast1,4,*

1School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, New York 11794-5000, USA
2NOAA Living Marine Resources Cooperative Science Center, Department of Natural Sciences, University of Maryland Eastern Shore, Princess Anne, Maryland 21853, USA
3NOAA National Ocean Service (NOS), Center for Coastal Environmental Health and Biomolecular Research (CCEHBR)/ Cooperative Oxford Laboratory, Oxford, Maryland 21654, USA
4Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, C1A 4P3, Canada
*Corresponding author. Email:

ABSTRACT: Striped bass Morone saxatilis were studied in order to characterize their immune responses over the short term following challenge with Mycobacterium marinum. The expression of immunity-related genes (IL-1β, TNF-α, Nramp and TGF-β) quickly increased following infection with M. marinum, but these genes were subsequently down-regulated despite the fact that bacterial counts remained high. The number of monocytes and neutrophils also initially increased at 1 d post-infection. This confirms the importance of these types of cells in initial inflammation and mycobacterial infection in striped bass. The phagocytic index of splenic leukocytes over these same time frames did not change significantly following infection. The discrete window in which inflammatory mechanisms were stimulated in striped bass may be related to the intracellular nature of this pathogen.

KEY WORDS: Mycobacteriosis · Striped bass · Gene expression · Interleukin-1β · IL-1β · Tumor necrosis factor-α · TNF-α · Natural resistance-associated macrophage protein · Nramp · Transforming growth factor-β · TGF-β

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Cite this article as: Jeon SJ, Gonsalves LC, Jacobs JM, Rhodes M and others (2011) Short-term infection of striped bass Morone saxatilis with Mycobacterium marinum. Dis Aquat Org 94:117-124.

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