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Diseases of Aquatic Organisms

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DAO 96:61-68 (2011)  -  DOI:

First description of an olfactory neuroblastoma in goldfish Carassius auratus: a case report

F. A. Vigliano1,2,*, A. J. Marcaccini1, J. Sarradell3, R. Bermúdez4, M. I. Quiroga5

1Cátedra de Histología y Embriología, 2Cátedra de Piscicultura, and 3Cátedra de Patología General y Especial, Facultad de Ciencias Veterinarias, Universidad Nacional de Rosario, S2170HGJ Casilda, Argentina
4Departamento de Anatomía y Producción Animal, and 5Departamento de Ciencias Clínicas Veterinarias, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain

ABSTRACT: An external pinkish growing mass that emerged from the right nostril of an adult goldfish Carassius auratus L. was evaluated by means of light microscopy and immunohistochemistry. The neoplasm presented a well-developed fibrovascular stroma associated with solid cell nests and a large number of Flexner-Wintersteiner rosettes. Myelinated fibres were observed around them. Neoplastic cells showed a prominent degree of nuclear atypia and low mitotic activity. The latter was in agreement with the low reactivity of tumour cells to anti-proliferating cell nuclear antigen antibody. Immunohistochemistry also revealed anti-neuronal nitric oxide synthase, anti-S100 protein, anti-­neuropeptide Y, and anti-cytokeratin immunoreactivity in tumour cells as well as in normal olfactory epithelium of goldfish control sections. Histopathological and immunohistochemical findings strongly suggest a diagnosis of an olfactory neuroblastoma (ONB). To our knowledge this is the first description of ONB in goldfish.

KEY WORDS: Tumour · Olfactory neuroblastoma · Goldfish · Carassius auratus · Histopathology · Immunohistochemistry

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Cite this article as: Vigliano FA, Marcaccini AJ, Sarradell J, Bermúdez R, Quiroga MI (2011) First description of an olfactory neuroblastoma in goldfish Carassius auratus: a case report. Dis Aquat Org 96:61-68.

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