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Diseases of Aquatic Organisms

    DAO prepress abstract   -  DOI:

    Spontaneous adenocarcinoma of the gas gland in Nothobranchius fishes

    Iva Dyková*, Radim Blažek, Kamila Součková, Martin Reichard, Ondřej Slabý

    *Corresponding author:

    ABSTRACT: Nothobranchius fishes (Cyprinodontiformes), known for their genetically encoded extremely compressed lifespan, are considered an excellent vertebrate model for the research of aging. Unlike the rapid progress in the knowledge of their biology, ecology and genomic data, the knowledge of their age-related diseases including tumours is still very limited. This note reports spontaneous neoplastic lesions in the swim bladder gas glands of Nothobranchius furzeri, N. kadleci and N. orthonotus. Based on light and transmission electron microscopy, the neoplastic proliferation of gas gland cells was classified as adenocarcinoma. There was a concurrent proliferation of hemopoietic cells in the kidney interstitium in all individuals diagnosed with this type of primary neoplasia.