DAO 84:243-250 (2009)  -  DOI: https://doi.org/10.3354/dao02052

Use of oxytetracycline for the treatment of tremor disease in the Chinese mitten crab Eriocheir sinensis

Tingming Liang, Qi Feng, Ting Wu, Wei Gu, Wen Wang*

Jiangsu Key Laboratory for Biodiversity & Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210046, PR China
*Corresponding author. Email:

ABSTRACT: The causative agent of tremor disease (TD) in the Chinese mitten crab Eriocheir sinensis has been shown to be a member of the genus Spiroplasma. In the present study, a susceptibility test indicated that oxytetracycline (OTC) has both a high degree of efficacy in the inhibition of Spiroplasma and a broad range of safe concentrations. Treatment experiments showed that the best concentration of OTC for use against TD was 40 mg OTC kg–1 crab weight. Acute toxicity experiments demonstrated that the 24 and 48 h median lethal dosages (LD50) of OTC for this species of crab were 366 and 340 mg OTC kg–1 crab body weight, respectively, while the safe concentration was 82.5 mg OTC kg–1 crab weight. We suggest that OTC has potential as a highly effective inhibitor of Spiroplasma pathogens in aquatic animals and has been proven to be a potent, safe and low cost cure for TD. This represents a novel use of OTC in the therapeutic treatment of an aquacultural disease caused by a Spiroplasma pathogen.


KEY WORDS: Oxytetracycline · Spiroplasma · Tremor disease · Acute toxicity · Chinese mitten crab · Eriocheir sinensis


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Cite this article as: Liang T, Feng Q, Wu T, Gu W, Wang W (2009) Use of oxytetracycline for the treatment of tremor disease in the Chinese mitten crab Eriocheir sinensis. Dis Aquat Org 84:243-250. https://doi.org/10.3354/dao02052

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